Convert kW to BTU/hr first by multiplying by 3,412.142.
The 500 constant is water doing the work: 8.33 lb per gallon × 60 minutes per hour × 1 BTU per lb·°F. Change the fluid and the constant changes with it.
In SI units the same relationship is L/s = kW ÷ (4.18 × ΔT in °C), where 4.18 is the specific heat of water in kJ/kg·K.
Note: Assumes plain water; glycol mixtures need a correction factor.